| DOI: | 10.2172/1037011
|
| 报告号: | DOEER64347
|
| 报告题名: | Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs |
| 作者: | Michael Cornforth
|
| 出版年: | 2012
|
| 发表日期: | 2012-03-26
|
| 国家: | 美国
|
| 语种: | 英语
|
| 英文关键词: | Ionizing radiation
; chromosome aberrations
; low dose
; LET
|
| 英文摘要: | Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. Specific aims apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. The project includes research complementary to NASA/HRP space radiation project. |
| URL: | http://www.osti.gov/scitech/servlets/purl/1037011
|
| Citation statistics: |
|
| 资源类型: | 研究报告
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/40863
|
| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
|
| File Name/ File Size |
Content Type |
Version |
Access |
License |
|
|---|
| 1037011.pdf（756KB） | 研究报告 | -- | 开放获取 | | View
Download
|
|
| Recommended Citation: | |
Michael Cornforth. Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs. 2012-01-01.
|
|
|