DOI: 10.1111/gcb.13548
论文题名: Precision wildlife medicine: applications of the human-centred precision medicine revolution to species conservation
作者: Whilde J. ; Martindale M.Q. ; Duffy D.J.
刊名: Global Change Biology
ISSN: 13541013
出版年: 2017
卷: 23, 期: 5 起始页码: 1792
结束页码: 1805
语种: 英语
英文关键词: chytridiomycosis
; EcoHealth
; emerging disease
; environmental DNA (eDNA)
; epizootic disease
; fibropapillomatosis
; One Health
; systems medicine
; wildlife cancer
; wildlife disease
Scopus关键词: Amphibia
; Animalia
; Cheloniidae
; Sarcophilus harrisii
英文摘要: The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal–human–ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary-based understanding of both wildlife and human diseases. © 2016 John Wiley & Sons Ltd 资助项目: Warmest thanks to the veterinary and rehabilitation staff of the Sea Turtle Hospital at the Whitney Laboratory for such stimulating discussions: Catherine Eastman, Rachel Thomas, Brooke Burkhalter, Devon Rollinson and Steven Nelson. We are also grateful to three anonymous reviewers whose comments helped to improve and strengthen the manuscript. Funding was generously provided by the Save Our Seas Foundation under project number SOSF 356.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/60964
Appears in Collections: 影响、适应和脆弱性
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作者单位: The Whitney Laboratory for Marine Bioscience & Sea Turtle Hospital, University of Florida, 9505 Ocean Shore Blvd, St. Augustine, FL, United States; Systems Biology Ireland, Science Link Building, University College Dublin, Belfield, Dublin 4, Ireland
Recommended Citation:
Whilde J.,Martindale M.Q.,Duffy D.J.. Precision wildlife medicine: applications of the human-centred precision medicine revolution to species conservation[J]. Global Change Biology,2017-01-01,23(5)