DOI: 10.1016/j.atmosenv.2014.04.003
Scopus记录号: 2-s2.0-84908305819
论文题名: Toxicological effects of polycyclic aromatic hydrocarbons and their derivatives on respiratory cells
作者: Koike E ; , Yanagisawa R ; , Takano H
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2014
卷: 97 起始页码: 529
结束页码: 536
语种: 英语
英文关键词: Bronchial epithelial cells
; Intracellular signaling pathway
; Polycyclic aromatic hydrocarbons
; Proinflammatory cytokines
Scopus关键词: Epithelial cells
; Intracellular signaling pathways
; Pro-inflammatory cytokines
; Toxicological effects
; Polycyclic aromatic hydrocarbons
; 1 nitropyrene
; 2 (2 amino 3 methoxyphenyl)chromone
; 4 (3 chloroanilino) 6,7 dimethoxyquinazoline
; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole
; cell nucleus receptor
; epidermal growth factor receptor
; fulvestrant
; hormone receptor blocking agent
; intercellular adhesion molecule 1
; interleukin 6
; interleukin 8
; ligand
; naphthalene
; naphthoquinone
; phenanthrene
; phenanthrenequinone
; polycyclic aromatic hydrocarbon
; polycyclic aromatic hydrocarbon derivative
; protein tyrosine kinase inhibitor
; pyrene
; pyrene derivative
; thyroid hormone receptor
; aerosol
; enzyme
; functional group
; gene expression
; health impact
; immune system
; inhibitor
; naphthalene
; PAH
; phenanthrene
; pyrene
; toxicology
; Article
; bronchial epithelium cell
; cell density
; cell viability
; comparative study
; controlled study
; cytokine production
; cytotoxicity
; epithelium cell
; flow cytometry
; human
; human cell
; human cell culture
; immune system
; in vitro study
; intracellular signaling
; ligand binding
; normal human
; protein expression
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Polycyclic aromatic hydrocarbons (PAHs) are found in ambient aerosols and particulate matter. Experimental studies have shown that PAHs and related chemicals can induce toxicological effects. The present study aimed to investigate the effects of PAHs and their derivatives on the respiratory and immune systems and the underlying mechanisms. The human bronchial epithelial cell line BEAS-2B was exposed to PAHs and their derivatives, and the cytotoxicity and proinflammatory protein expression were then investigated. A cytotoxic effect was observed in BEAS-2B exposed to PAH derivatives such as naphthoquinone (NQ), phenanthrenequinone (PQ), 1-nitropyrene (1-NP), and 1-aminopyrene (1-AP). In addition, 1,2-NQ and 9,10-PQ showed more effective cytotoxicity than 1,4-NQ and 1,4-PQ, respectively. Pyrene showed a weak cytotoxic effect. On the other hand, naphthalene and phenanthrene showed no significant effects. Pyrene, 1-NP, and 1-AP also increased intercellular adhesion molecule-1 expression and interleukin-6 production in BEAS-2B. The increase was partly suppressed by protein kinase inhibitors such as the epidermal growth factor receptor-selective tyrosine kinase inhibitor and nuclear receptor antagonists such as the thyroid hormone receptor antagonist. The present study suggests that the toxicological effects of chemicals may be related to the different activities resulting from their structures, such as numbers of benzene rings and functional groups. Furthermore, the chemical-induced increase in proinflammatory protein expression in bronchial epithelial cells was possibly a result of the activation of protein kinase pathways and nuclear receptors. The increase may partly contribute to the adverse health effects of atmospheric PAHs. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/80594
Appears in Collections: 气候变化事实与影响
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作者单位: Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, Japan; Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Nishikyo-ku, Kyoto, Japan
Recommended Citation:
Koike E,, Yanagisawa R,, Takano H. Toxicological effects of polycyclic aromatic hydrocarbons and their derivatives on respiratory cells[J]. Atmospheric Environment,2014-01-01,97