DOI: 10.1016/j.atmosenv.2015.05.050
Scopus记录号: 2-s2.0-84937948376
论文题名: Atmospheric concentration and carcinogenic risk of polycyclic aromatic hydrocarbons including benzo[c]fluorene, cyclopenta[c,d]pyrene, and benzo[j]fluoranthene in Japan
作者: Yagishita M ; , Kageyama S ; , Ohshima S ; , Matsumoto M ; , Aoki Y ; , Goto S ; , Nakajima D
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2015
卷: 115 起始页码: 263
结束页码: 268
语种: 英语
英文关键词: Benzo[a]pyrene
; Benzo[c]fluorene
; Carcinogenic risk
; Gaseous PAHs
; Particulate PAHs
Scopus关键词: Aromatic compounds
; Aromatic hydrocarbons
; Environmental Protection Agency
; Gases
; Hydrocarbons
; Ionization of gases
; Pyrene
; Risk assessment
; Benzo [a] pyrene
; Carcinogenic risk
; Fluorenes
; Gaseous PAHs
; Particulate PAHs
; Polycyclic aromatic hydrocarbons
; benzo[c]fluorene
; benzo[j]fluoranthene
; cyclopenta[c,d]pyrene
; fluoranthene
; fluorene derivative
; polycyclic aromatic hydrocarbon
; pyrene derivative
; unclassified drug
; air sampling
; atmospheric pollution
; cancer
; carcinogen
; dose-response relationship
; gas phase reaction
; health risk
; PAH
; public health
; pyrene
; rodent
; toxic substance
; air pollution
; Article
; atmosphere
; cancer risk
; carcinogenicity
; dose calculation
; gas
; mouse
; nonhuman
; phase partitioning
; priority journal
; slope factor
; summer
; winter
; Japan
; Mus
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: The atmospheric concentrations of both gas-phase and particulate-phase polycyclic aromatic hydrocarbons (PAHs) including 16 US Environmental Protection Agency priority PAHs (16 PAHs) were measured in eleven cities across Japan. Using the measured average concentrations and toxic equivalency factors (TEF) of the 16 PAHs, the benzo[a]pyrene (BaP)-toxic equivalent for eight major PAHs was obtained: the ratio of BaP to the eight major PAH toxicities ranged from 0.23 to 0.47. Among the target PAHs, from the viewpoint of carcinogenicity, we focused on benzo[. c]fluorene (BcFE), which was detected in both the gas and particulate phase in contrast to BaP. The relative potency factor (RPF) of BcFE was evaluated as 6.46 based on its cancer slope factor relative to that of BaP determined in the benchmark dose calculations for mice. The relative carcinogenic risk of BcFE to BaP was obtained by multiplying the averaged concentrations of BaP and BcFE by the RPF value: the risk of BcFE was 6.8 and 5.1 times higher than that of BaP in summer and winter, respectively. These results show that the collection of atmospheric samples including the gas phase is important when assessing the carcinogenic risk of atmospheric PAHs. © 2015 The Authors. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/81685
Appears in Collections: 气候变化事实与影响
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作者单位: Department of Environmental Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan; National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, Japan; Department of Food and Nutrition, Faculty of Home Economics, Koriyama Women's University and College, 3-25-2 Kaisei, Koriyama, Fukushima, Japan; College of Environmental Health, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa, Japan
Recommended Citation:
Yagishita M,, Kageyama S,, Ohshima S,et al. Atmospheric concentration and carcinogenic risk of polycyclic aromatic hydrocarbons including benzo[c]fluorene, cyclopenta[c,d]pyrene, and benzo[j]fluoranthene in Japan[J]. Atmospheric Environment,2015-01-01,115