DOI: 10.1016/j.atmosenv.2015.02.014
Scopus记录号: 2-s2.0-84922455196
论文题名: Surface area as a dose metric for carbon black nanoparticles: A study of oxidative stress, DNA single-strand breakage and inflammation in rats
作者: Chuang H ; -C ; , Chen L ; -C ; , Lei Y ; -C ; , Wu K ; -Y ; , Feng P ; -H ; , Cheng T ; -J
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2015
卷: 106 起始页码: 329
结束页码: 334
语种: 英语
英文关键词: 8-Hydroxy-2'-deoxyguanosine
; Carbon black
; DNA single-strand breakage
; Nanoparticle
; Surface area
Scopus关键词: Biomolecules
; Carbon
; Coal breakage
; DNA
; Nanoparticles
; Rats
; Toxicity
; 8-Hydroxy-2'-deoxyguanosine
; Carbon black nanoparticles
; High surface area
; Intratracheal instillation
; Oxidative potential
; Spontaneously hypertensive rats
; Strand breakage
; Surface area
; Carbon black
; 8 hydroxydeoxyguanosine
; black carbon
; carbon nanoparticle
; lactate dehydrogenase
; single stranded DNA
; black carbon
; combustion
; DNA
; injury
; nanotechnology
; oxidation
; rodent
; surface area
; animal cell
; animal experiment
; animal model
; Article
; blood cell
; cell infiltration
; cell membrane permeability
; cell surface
; controlled study
; cytotoxicity
; DNA strand breakage
; inflammation
; lactate dehydrogenase blood level
; lung alveolus cell
; macrophage
; male
; neutrophil chemotaxis
; neutrophil count
; nonhuman
; oxidative stress
; priority journal
; rat
; spontaneously hypertensive rat
; Rattus
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Combustion-derived nanoparticles are characterised by a high surface area (SA) per mass. SA is proposed to regulate the bioreactivity of nanoparticles; however, the dose metric for carbon black remains controversial. To determine the relationships between bioreactivity and SA, male spontaneously hypertensive rats were exposed to carbon black (CB) nanoparticles (15, 51 and 95nm) via intratracheal instillation for 24h. Pulmonary exposure to CB resulted in a significant increase in systemic 8-hydroxy-2'-deoxyguanosine (8-OHdG), DNA single-strand breakages in peripheral blood cells and pulmonary cell infiltration in rats. The oxidative potential and particularly the corresponding SA of CB were correlated with the level of 8-OHdG, DNA single-strand breakages and pulmonary cell infiltration in rats. We conclude that SA is an important dose metric for CB that can regulate oxidative stress and DNA damage in rats. Furthermore, this observation was more significant for smaller sized CB. © 2015 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/81929
Appears in Collections: 气候变化事实与影响
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作者单位: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
Recommended Citation:
Chuang H,-C,, Chen L,et al. Surface area as a dose metric for carbon black nanoparticles: A study of oxidative stress, DNA single-strand breakage and inflammation in rats[J]. Atmospheric Environment,2015-01-01,106