globalchange  > 气候变化事实与影响
DOI: 10.1016/j.atmosenv.2014.12.051
Scopus记录号: 2-s2.0-84922949431
论文题名:
In vitro and in vivo toxicity of urban and rural particulate matter from California
作者: Mirowsky J; E; , Jin L; , Thurston G; , Lighthall D; , Tyner T; , Horton L; , Galdanes K; , Chillrud S; , Ross J; , Pinkerton K; E; , Chen L; C; , Lippmann M; , Gordon T
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2015
卷: 103
起始页码: 256
结束页码: 262
语种: 英语
英文关键词: Aspiration exposure ; Inflammation ; Invitro exposure ; Particulate matter ; Reactive oxygen species
Scopus关键词: Cell culture ; Endothelial cells ; Mammals ; Oxygen ; Particle size ; Particles (particulate matter) ; Toxicity ; Trace analysis ; Trace elements ; Aspiration exposure ; In-vitro ; Inflammation ; Particulate Matter ; Reactive oxygen species ; Urban growth ; antimony ; arsenic ; calcium ; chromium ; copper ; endotoxin ; iron ; lead ; manganese ; nickel ; potassium ; reactive oxygen metabolite ; selenium ; sulfur ; titanium ; trace metal ; vanadium ; zinc ; atmospheric pollution ; chemical composition ; concentration (composition) ; correlation ; numerical model ; particle size ; particulate matter ; pollutant source ; pollution exposure ; rodent ; rural area ; toxicity ; toxin ; trace metal ; urban area ; air pollution ; animal experiment ; animal model ; Article ; biomass ; capillary endothelial cell ; chemical composition ; controlled study ; female ; human ; human cell ; in vitro study ; in vivo study ; male ; mouse ; nonhuman ; oxidative stress ; particle size ; particulate matter ; priority journal ; rural area ; toxicity ; United States ; urban area ; California ; United States ; Mus
Scopus学科分类: Environmental Science: Water Science and Technology ; Earth and Planetary Sciences: Earth-Surface Processes ; Environmental Science: Environmental Chemistry
英文摘要: Particulate matter (PM) varies in chemical composition and mass concentration based on location, source, and particle size. This study sought to evaluate the invitro and invivo toxicity of coarse (PM10-2.5) and fine (PM2.5) PM samples collected at 5 diverse sites within California. Coarse and fine PM samples were collected simultaneously at 2 rural and 3 urban sites within California during the summer. A human pulmonary microvascular endothelial cell line (HPMEC-ST1.6R) was exposed to PM suspensions (50μg/mL) and analyzed for reactive oxygen species (ROS) after 5h of treatment. In addition, FVB/N mice were exposed by oropharyngeal aspiration to 50μg PM, and lavage fluid was collected 24h post-exposure and analyzed for total protein and %PMNs. Correlations between trace metal concentrations, endotoxin, and biological endpoints were calculated, and the effect of particle size range, locale (urban vs. rural), and location was determined. Absolute principal factor analysis was used to identify pollution sources of PM from elemental tracers of those sources. Ambient PM elicited an ROS and pro-inflammatory-related response in the cell and mouse models, respectively. These responses were dependent on particle size, locale, and location. Trace elements associated with soil and traffic markers were most strongly linked to the adverse effects invitro and invivo. Particle size, location, source, and composition of PM collected at 5 locations in California affected the ROS response in human pulmonary endothelial cells and the inflammatory response in mice. © 2014 Elsevier Ltd.
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/82035
Appears in Collections:气候变化事实与影响

Files in This Item:

There are no files associated with this item.


作者单位: New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, NY, United States; San Joaquin Valley Air Pollution Control District, Fresno, CA, United States; Clinical Research Center, Department of Medicine, Fresno, CA, United States; Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY, United States; Center for Health and the Environment, University of California-Davis, Davis, CA, United States

Recommended Citation:
Mirowsky J,E,, Jin L,et al. In vitro and in vivo toxicity of urban and rural particulate matter from California[J]. Atmospheric Environment,2015-01-01,103
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mirowsky J]'s Articles
[E]'s Articles
[, Jin L]'s Articles
百度学术
Similar articles in Baidu Scholar
[Mirowsky J]'s Articles
[E]'s Articles
[, Jin L]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mirowsky J]‘s Articles
[E]‘s Articles
[, Jin L]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.