DOI: 10.1016/j.atmosenv.2018.03.031
Scopus记录号: 2-s2.0-85044128341
论文题名: Evaluation of cellular effects of fine particulate matter from combustion of solid fuels used for indoor heating on the Navajo Nation using a stratified oxidative stress response model
作者: Li N ; , Champion W ; M ; , Imam J ; , Sidhu D ; , Salazar J ; R ; , Majestic B ; J ; , Montoya L ; D
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2018
卷: 182 起始页码: 87
结束页码: 96
语种: 英语
英文关键词: Heme oxygenase-1
; Inflammation
; Native Nation
; Residential solid fuel heating
; Stratified cellular oxidative stress response
; Tumor necrosis factor alpha
Scopus关键词: Antioxidants
; Cell death
; Coal
; Fuels
; Glycoproteins
; Health
; Macrophages
; Nickel
; Organic carbon
; Oxidative stress
; Particles (particulate matter)
; Pathology
; Porphyrins
; Stoves
; Suspensions (fluids)
; Tumors
; Wood
; Heme oxygenase-1
; Inflammation
; Native Nation
; Oxidative stress response
; Solid fuels
; Tumor necrosis factor alpha
; Coal combustion
; carbon
; coal
; copper
; fuel
; heme oxygenase 1
; nickel
; organic carbon
; potassium
; tumor necrosis factor
; antioxidant
; cardiovascular disease
; coal combustion
; combustion
; concentration (composition)
; coniferous tree
; elemental carbon
; enzyme
; enzyme activity
; health impact
; heating
; indoor air
; oxidative stress
; particulate matter
; pollution exposure
; proteomics
; public health
; toxicity
; wood
; animal cell
; Article
; cell death
; cell viability
; combustion
; controlled study
; cytokine release
; cytotoxicity
; heating
; indoor air pollution
; inflammation
; Juniperus
; macrophage
; mouse
; Navajo (people)
; nonhuman
; oxidative stress
; particulate matter
; ponderosa pine
; priority journal
; RAW 264.7 cell line
; wood
; Arizona
; Navajo County
; United States
; Juniperus osteosperma
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Communities in the Navajo Nation face public health burdens caused in part by the combustion of wood and coal for indoor heating using stoves that are old or in disrepair. Wood and coal combustion emits particulate matter (PM) with aerodynamic diameter < 2.5 μm (PM2.5), which can reach deep in the lung and cause injuries. Currently, there is little information about the health effects of wood and coal combustion-derived PM2.5 on Navajo Nation residents. This study tested the hypothesis that PM2.5 generated from solid fuel combustion in stoves commonly used by Navajo residents would induce stratified oxidative stress responses ranging from activation of antioxidant defense to inflammation and cell death in mouse macrophages (RAW 264.7). PM2.5 emitted from burning Ponderosa Pine (PP) and Utah Juniper (UJ) wood and Black Mesa (BM) and Fruitland (FR) coal in a stove representative of those widely used by Navajo residents were collected, and their aqueous suspensions used for cellular exposure. PM from combustion of wood had significantly more elemental carbon (EC) (15%) and soluble Ni (0.0029%) than the samples from coal combustion (EC: 3%; Ni: 0.0019%) and was also a stronger activator of antioxidant enzyme heme oxygenase-1 (11-fold increase vs. control) than that from coal (5-fold increase). Only PM from PP-wood (12-fold) and BM-coal (3-fold) increased the release of inflammatory cytokine tumor necrosis factor alpha. Among all samples, PP-wood consistently had the strongest oxidative stress and inflammatory effects. PM components, i.e. low-volatility organic carbon, EC, Cu, Ni and K were positively correlated with the cellular responses. Results showed that, at the concentrations tested, emissions from all fuels did not have significant cytotoxicity. These findings suggest that PM2.5 emitted from combustion of wood and coal commonly used by Navajo residents may negatively impact the health of this community. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/82891
Appears in Collections: 气候变化事实与影响
There are no files associated with this item.
作者单位: Michigan State University, Department of Pathobiology and Diagnostic Investigation, CVM, 1129 Farm Ln., East Lansing, MI, United States; University of Colorado Boulder, Civil, Environmental, and Architectural Engineering Department, 1111 Engineering Drive, ECOT 441, UCB 428, Boulder, CO, United States; University of Colorado Boulder, Molecular, Cellular, and Developmental Biology Department, UCB 347, Boulder, CO, United States; University of Denver, Department of Chemistry and Biochemistry, 2190 E. Iliff Ave., Denver, CO, United States
Recommended Citation:
Li N,, Champion W,M,et al. Evaluation of cellular effects of fine particulate matter from combustion of solid fuels used for indoor heating on the Navajo Nation using a stratified oxidative stress response model[J]. Atmospheric Environment,2018-01-01,182