DOI: 10.1016/j.atmosenv.2017.12.021
Scopus记录号: 2-s2.0-85039787001
论文题名: Genotoxic effects of daily personal exposure to particle mass and number concentrations on buccal cells
作者: de Almeida D ; S ; , da Costa S ; C ; , Ribeiro M ; , Moreira C ; A ; B ; , Beal A ; , Squizzato R ; , Rudke A ; P ; , Rafee S ; A ; A ; , Martins J ; A ; , Palioto G ; F ; , Kumar P ; , Martins L ; D
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2018
卷: 176 起始页码: 148
结束页码: 157
语种: 英语
英文关键词: Air pollution
; DNA damage
; Fine particulate matter
; Personal exposure
Scopus关键词: Air pollution
; Commerce
; Commercial vehicles
; DNA
; Exposure controls
; Nucleic acids
; Commercial services
; DNA damages
; Fine particulate matter
; Mass concentration
; Number concentration
; Particle number concentration
; Particulate Matter
; Personal exposures
; Particles (particulate matter)
; DNA
; atmospheric pollution
; bioassay
; cells and cell components
; concentration (composition)
; DNA
; genotoxicity
; occupational exposure
; particle size
; particulate matter
; pollution effect
; pollution exposure
; public health
; traffic emission
; urban area
; working conditions
; Article
; Brazil
; cheek cell
; comet assay
; concentration (parameters)
; controlled study
; DNA damage
; environmental exposure
; genotoxicity
; human
; human cell
; mass
; particle number concentration
; particulate matter
; priority journal
; urban area
; work
; workplace
; Brazil
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: The aim of this study is to assess personal exposure to Particle Number Concentrations (PNC) in four size ranges between 0.3 and 10 μm, and particulate matter (PM1; PM2.5; PM4; PM10) in order to evaluate possible genotoxic effects through a comet assay in buccal cells. A convenience cohort of 30 individuals from a Brazilian medium-sized city was selected. These individuals aged between 20 and 61 and worked in typical job categories (i.e., administrative, commerce, education, general services and transport). They were recruited to perform personal exposure measurements during their typical daily routine activities, totaling 240 h of sampling. The 8-h average mass concentrations in air for volunteers ranged from 2.4 to 31.8 μg m−3 for PM1, 4.2–45.1 μg m−3 for PM2.5, 7.9–66.1 μg m−3 for PM4 and from 23.1 to 131.7 μg m−3 for PM10. The highest PNC variation was found for 0.3–0.5 range, between 14 and 181 particles cm−3, 1 to 14 particles cm−3 for the 0.5–1.0 range, 0.2 to 2 particles cm−3 for the 1.0–2.5 range, and 0.06 to 0.7 particles cm−3 for the 2.5–10 range. Volunteers in the ‘education’ category experienced the lowest inhaled dose of PM2.5 as opposed to those involved in ‘commercial‘ activities with the highest doses for PM10 (1.63 μg kg−1 h−1) and PM2.5 (0.61 μg kg−1 h−1). The predominant cause for these high doses was associated with the proximity of the workplace to the street and vehicle traffic. The comet assay performed in buccal cells indicated that the volunteers in ‘commerce’ category experienced the highest damage to their DeoxyriboNucleic Acid (DNA) compared with the control category (i.e. ‘education’). These results indicate the variability in personal exposure of the volunteers in different groups, and the potential damage to DNA was much higher for those spending time in close proximity to the vehicle sources (e.g. commercial services) leading to exposure to a higher fraction of fine particles. This study builds understanding on the exposure of people in different job categories, and provide policy makers with useful information to tackle this neglected issue. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/83006
Appears in Collections: 气候变化事实与影响
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作者单位: Federal University of Technology – Paraná, Avenida dos Pioneiros, 3131, Londrina, Brazil; State University of Maringa –Colombo Avenue, 5790, Vila Esperança, Maringa, Brazil; State University of Londrina –Rodovia Celso Garcia Cid, Pr 445, km 380, Londrina, Brazil; University of São Paulo – Rua do Matão, 1226 – Cidade Universitária, São Paulo, SP, Brazil; Global Centre for Clean Air Research (GCARE), Department of Civil and Environmental Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom; Visiting Researcher at Lund University, Lund, Sweden
Recommended Citation:
de Almeida D,S,, da Costa S,et al. Genotoxic effects of daily personal exposure to particle mass and number concentrations on buccal cells[J]. Atmospheric Environment,2018-01-01,176