globalchange  > 过去全球变化的重建
DOI: 10.1016/j.marpolbul.2014.01.042
Scopus记录号: 2-s2.0-84906256055
论文题名:
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)
作者: Nakayama K.; Inoue Y.; Ikeda N.; Hashizume N.; Murakami H.; Ishibashi T.; Ikeda H.; Isobe T.; Kitamura S.-I.; Suzuki G.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2014
卷: 85, 期:2
起始页码: 370
结束页码: 375
语种: 英语
英文关键词: Bioconcentration factor ; Blood cell composition ; Common carp ; Free amino acid ; Glucocorticoid ; Glucose
Scopus关键词: Amino acids ; Blood ; Fish ; Glucose ; Hormones ; Volatile fatty acids ; Bio-concentration factors ; Blood cells ; Common carp ; Free amino acids ; Glucocorticoid ; Biomarkers ; amino acid ; clobetasol propionate ; clobetasone butyrate ; glucose ; amino acid ; clobetasol ; clobetasone butyrate ; glucocorticoid ; glucose blood level ; amino acid ; bioaccumulation ; blood ; cyprinid ; glucose ; hormone ; protein ; serum ; steroid ; amino acid blood level ; animal cell ; article ; bioaccumulation ; biological activity ; carp ; concentration response ; controlled study ; energy metabolism ; environmental monitoring ; erythrocyte count ; glucose blood level ; hormone action ; hormone transport ; leukocyte count ; nonhuman ; protein degradation ; analogs and derivatives ; animal ; blood ; carp ; drug effects ; metabolism ; physiology ; Cyprinus carpio ; Amino Acids ; Animals ; Blood Glucose ; Carps ; Clobetasol ; Erythrocyte Count ; Glucocorticoids ; Leukocyte Count ; Proteolysis
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science ; Earth and Planetary Sciences: Oceanography ; Environmental Science: Pollution
英文摘要: Uptake and biological effects of synthetic glucocorticoids (GCs) were analyzed using common carp (Cyprinus carpio). Fish were exposed to clobetasol propionate (CP) or clobetasone butyrate (CB) individually or in mixture at 1 μ g L-1 for 21days. Bioconcentration factor (BCF) of CB was calculated as 100, and BCF of CP was less than 16. No effects were found in fish erythrocyte and leukocyte numbers and serum glucose levels after exposure to the selected GCs. On the other hand, serum concentrations of free amino acids significantly increased in GC-exposed groups. Thus, exposures to synthetic GCs at relatively low concentrations seemed to cause enhancement of protein degradation and subsequent increase of serum free amino acids without a corresponding increase in serum glucose levels, an effect which might be related to partial induction of gluconeogenesis by GC. © 2014 Elsevier Ltd.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/85325
Appears in Collections:过去全球变化的重建
全球变化的国际研究计划

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作者单位: Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan; Chemicals Evaluation and Research Institute, Japan, CERI Kurume, 3-2-7 Miyanojin, Kurume 839-0801, Japan; National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan

Recommended Citation:
Nakayama K.,Inoue Y.,Ikeda N.,et al. Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)[J]. Marine Pollution Bulletin,2014-01-01,85(2)
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