DOI: 10.1016/j.marpolbul.2014.05.023
Scopus记录号: 2-s2.0-84906276958
论文题名: Benzo[a]pyrene modulates the biotransformation, DNA damage and cortisol level of red sea bream challenged with lipopolysaccharide
作者: Bo J. ; Gopalakrishnan S. ; Chen F.-Y. ; Wang K.-J.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2014
卷: 85, 期: 2 起始页码: 463
结束页码: 470
语种: 英语
英文关键词: Adverse outcome pathway
; Benzo[a]pyrene
; Cytochrome P4501A1
; DNA damage
; EROD activity
Scopus关键词: Bioconversion
; DNA
; Pyrene
; Adverse outcomes
; Benzo [a] pyrene
; Biotransformation system
; DNA damages
; Environmental concentration
; EROD activity
; Lipopolysaccharides
; Short-term exposure
; Cortisol
; benzo[a]pyrene
; cytochrome P450 1A1
; DNA
; hydrocortisone
; lipopolysaccharide
; benzo[a]pyrene
; cytochrome P450 1A1
; hydrocortisone
; lipopolysaccharide
; biomarker
; biotransformation
; cytochrome
; DNA
; enzyme activity
; immune system
; PAH
; perciform
; steroid
; toxicity
; article
; bioaccumulation
; biotransformation
; blood sampling
; concentration (parameters)
; controlled study
; DNA damage
; environmental exposure
; enzyme activity
; hydrocortisone blood level
; immune response
; juvenile animal
; nonhuman
; Pagrus major
; protein expression
; sea bream
; water contamination
; animal
; biotransformation
; fish
; liver
; metabolism
; sea bream
; Animalia
; Archosargus rhomboidalis
; Pagrus major
; Animals
; Benzo(a)pyrene
; Biotransformation
; Cytochrome P-450 CYP1A1
; DNA Damage
; Fishes
; Hydrocortisone
; Lipopolysaccharides
; Liver
; Sea Bream
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: In animals, biotransformation and the immune system interact with each other, however, knowledge of the toxic mechanism of benzo[a]pyrene (BaP) on these two systems is not well known. The present study investigated the toxic effects of BaP on the biotransformation system, cortisol level and DNA integrity of red sea bream (Pagrus major). The results showed that cortisol level was induced under the challenge of lipopolysaccharide (LPS). Short-term exposure (96. h) of BaP at environmental concentration significantly increased the cortisol level, hepatic EROD activity and CYP1A1 mRNA expression. When P. major was exposed to BaP for 14 d followed by LPS challenge this increased the cortisol level, EROD activity and hepatic DNA damage except CYP1A1 mRNA expression. Combined with our previous data, which showed that BaP exposure can modulate the immunologic response in P. major challenged with LPS, a hypothetical adverse outcome pathway of BaP on fish was suggested. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/85350
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Third Institute of Oceanography, State Oceanic Administration, Xiamen, Fujian 361005, China; State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China
Recommended Citation:
Bo J.,Gopalakrishnan S.,Chen F.-Y.,et al. Benzo[a]pyrene modulates the biotransformation, DNA damage and cortisol level of red sea bream challenged with lipopolysaccharide[J]. Marine Pollution Bulletin,2014-01-01,85(2)