DOI: 10.1016/j.marpolbul.2014.11.014
Scopus记录号: 2-s2.0-84930755433
论文题名: Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds
作者: Alvarez-Muñoz D. ; Indiveri P. ; Rostkowski P. ; Horwood J. ; Greer E. ; Minier C. ; Pope N. ; Langston W.J. ; Hill E.M.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2015
卷: 95, 期: 2 起始页码: 590
结束页码: 597
语种: 英语
英文关键词: Anti-androgen
; AR-CALUX
; Clam
; Effect-directed analysis
; Endocrine disruption
; Sediment
Scopus关键词: Contamination
; Histology
; Molluscs
; Organic carbon
; Sediments
; Shellfish
; Tissue
; Androgen receptor antagonists
; Anti-androgen
; Clam
; Effect-directed analysis
; Endocrine disruption
; Polycyclic aromatic hydrocarbons (PAHS)
; Sexual differentiations
; Total Organic Carbon
; Polycyclic aromatic hydrocarbons
; androgen receptor
; androstanolone
; antiandrogen
; organic carbon
; polycyclic aromatic hydrocarbon
; antiandrogen
; polycyclic aromatic hydrocarbon
; water pollutant
; androgen
; biological uptake
; coastal sediment
; endocrine disruptor
; mollusc
; PAH
; physiological response
; pollution effect
; sediment pollution
; total organic carbon
; animal tissue
; Article
; clam
; coastal waters
; controlled study
; estuary
; extraction
; female
; France
; indicator organism
; male
; nonhuman
; Scrobicularia plana
; sea pollution
; sediment
; United Kingdom
; analysis
; animal
; aquatic species
; bivalve
; chemistry
; environmental monitoring
; Great Britain
; metabolism
; physiology
; sediment
; toxicity
; water pollutant
; France
; United Kingdom
; Bivalvia
; Scrobicularia plana
; Androgen Antagonists
; Animals
; Aquatic Organisms
; Bivalvia
; Environmental Monitoring
; Estuaries
; Female
; France
; Geologic Sediments
; Great Britain
; Male
; Polycyclic Hydrocarbons, Aromatic
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3. ±. 38.4. μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86038
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: School of Life Sciences, University of Sussex, Brighton, United Kingdom; Laboratory of Ecotoxicology, UPRES EA-3222, UFR de Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP 540, Le Havre Cedex, France; Marine Biological Association, The Laboratory, Citadel Hill, Plymouth, United Kingdom
Recommended Citation:
Alvarez-Muñoz D.,Indiveri P.,Rostkowski P.,et al. Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds[J]. Marine Pollution Bulletin,2015-01-01,95(2)