globalchange  > 过去全球变化的重建
DOI: 10.1016/j.marpolbul.2017.04.021
Scopus记录号: 2-s2.0-85018727479
论文题名:
Carboxylesterase activities in chondrichthyans of the western Mediterranean Sea
作者: Nos D.; Navarro J.; Barría C.; Solé M.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 119, 期:1
起始页码: 332
结束页码: 335
语种: 英语
英文关键词: Carboxylesterases ; Chondrichthyans ; Fenofibrate ; Marine ecosystem ; Organophosphates ; Pharmaceutical products
Scopus关键词: Aquatic ecosystems ; Biochemistry ; Detoxification ; Drug products ; Ecology ; Enzyme inhibition ; Enzymes ; Sensitivity analysis ; Substrates ; Carboxylesterases ; Chondrichthyans ; Fenofibrate ; Organophosphates ; Pharmaceutical products ; Ecosystems ; carboxylesterase ; fenofibrate ; bioaccumulation ; drug ; enzyme activity ; fish ; marine ecosystem ; PPCP ; predator ; xenobiotics ; analysis of variance ; Article ; bioaccumulation ; cartilaginous fish ; detoxification ; drug metabolism ; environmental monitoring ; enzyme activity ; enzyme kinetics ; IC50 ; lipid metabolism ; marine environment ; Mediterranean Sea ; nonhuman ; Scyliorhinus canicula ; species difference ; species diversity ; Mediterranean Sea ; Mediterranean Sea (West) ; Chimaeriformes ; Chondrichthyes ; Rajiformes ; Scyliorhinus canicula
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science ; Earth and Planetary Sciences: Oceanography ; Environmental Science: Pollution
英文摘要: Sharks, rays, skates and chimaeras play an important role as predators in the ecosystems. These species could serve as potential sentinels for the presence of xenobiotics in marine ecosystems. In this study, liver carboxylesterase (CbE) activity was determined for 20 species of chondrichthyans. Carboxylesterase activity, a known esterase involved in the metabolism of pesticides, lipids and certain drugs, was measured using two substrates: 4-nitrophenyl acetate (pNPA) and α-naphthyl acetate (αNA). Rajiformes (rays and skates) showed higher CbE activity than sharks, and the order Chimaeriformes showed the lowest values. In vitro sensitivity to CbE inhibitors was assessed in the shark Scyliorhinus canicula. The substrate αNA was found to be the most adequate as it displayed the highest activity and was more sensitive to the organophosphate dichlorvos in the liver (IC50 = 2.37 μM) and plasma (IC50 = 0.051 μM). The high interspecific variation of CbE activity and its sensitivity to inhibition by fenofibrate suggest that this enzyme could contribute to species-specific differences in drug detoxification. © 2017
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87601
Appears in Collections:过去全球变化的重建
全球变化的国际研究计划

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作者单位: Institut de Ciències del Mar CSIC, Passeig Marítim de la Barceloneta, 37-49, Barcelona, Spain; Estación Biológica de Doñana CSIC, Avenida Américo Vespucio 26, Sevilla, Spain

Recommended Citation:
Nos D.,Navarro J.,Barría C.,et al. Carboxylesterase activities in chondrichthyans of the western Mediterranean Sea[J]. Marine Pollution Bulletin,2017-01-01,119(1)
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