DOI: 10.1016/j.marpolbul.2017.03.067
Scopus记录号: 2-s2.0-85017156041
论文题名: Using a multi-biomarker approach to assess the effects of pollution on sand flathead (Platycephalus bassensis) from Port Phillip Bay, Victoria, Australia
作者: Fu D. ; Bridle A. ; Leef M. ; Gagnon M.M. ; Hassell K.L. ; Nowak B.F.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 119, 期: 1 起始页码: 211
结束页码: 219
语种: 英语
英文关键词: Biomarkers
; Gene expression
; Histology
; Port Phillip Bay
; Sand flathead
Scopus关键词: Biomarkers
; Cell death
; Cell membranes
; Environmental impact
; Fish
; Genes
; Histology
; Pollution
; Apoptosis-related genes
; Comprehensive information
; Endoplasmic reticulum stress
; Environmental pollutants
; Hepatic gene expressions
; Multi-biomarker approaches
; Port Phillip Bay
; Positive correlations
; Gene expression
; cytochrome P450 1A1
; ferritin
; glucose regulated protein 78
; thyroid hormone
; biological marker
; apoptosis
; biomarker
; fish
; gene expression
; histology
; metabolism
; pollution effect
; animal tissue
; Article
; Australia
; CYP1A gene
; D1 gene
; D2 gene
; Diablo gene
; endoplasmic reticulum stress
; environmental monitoring
; female
; Ferritin gene
; fish
; FPN1 gene
; gene
; gene expression
; genetic analysis
; genetic transcription
; genetic transfection
; geographic distribution
; GRP78 gene
; hormone action
; male
; MT gene
; MTF1 gene
; nonhuman
; Platycephalus bassensis
; pollution
; quantitative analysis
; reverse transcription polymerase chain reaction
; SMAC1 gene
; SMAC2 gene
; TF gene
; TRalpha gene
; TRbeta gene
; TTR gene
; upregulation
; water pollution
; water quality
; water sampling
; animal
; bay
; fish
; genetic marker
; metabolism
; toxicity
; Victoria
; water pollutant
; Australia
; Port Phillip Bay
; Victoria [Australia]
; Kathetostoma giganteum
; Platycephalus arenarius
; Platycephalus bassensis
; Animals
; Bays
; Biomarkers
; Female
; Fishes
; Genetic Markers
; Victoria
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Hepatic gene expression and liver histology were examined in sand flathead (Platycephalus bassensis) from six locations in Port Phillip Bay, Victoria, Australia. Four sets of genes including thyroid-related genes (D1, D2, TTR, TRα and TRβ), metal metabolism-related genes (MT, MTF1, TF, Ferritin and FPN1), apoptosis-related genes (Diablo/SMAC1, Diablo/SMAC2 and CYP1A) and an endoplasmic reticulum stress biomarker gene (GRP78) were examined in female flathead using qRT-PCR. TRβ and Diablo/SMAC1 gene expression was significantly up-regulated in fish from all polluted sites compared to those from a reference site. The transcripts of TRα and FPN1 were significantly higher in flathead from Corio Bay, while the hepatic mRNA of TTR and GRP78 were significantly lower in those fish. Positive correlations were observed between Diablo/SMAC1 and CYP1A, D2 and TRβ, TRα and TRβ. This study demonstrates that application of pathway-based biomarker genes and histopathology can provide comprehensive information on the impact of environmental pollutants on fish. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87618
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Institute for Marine and Antarctic Studies, University of Tasmania, Locked Bag 1370, Launceston, Tasmania, Australia; Department of Environment & Agriculture, Curtin University, Bentley, Western Australia, Australia; Centre for Aquatic Pollution Identification and Management (CAPIM), The University of Melbourne, Parkville, Victoria, Australia
Recommended Citation:
Fu D.,Bridle A.,Leef M.,et al. Using a multi-biomarker approach to assess the effects of pollution on sand flathead (Platycephalus bassensis) from Port Phillip Bay, Victoria, Australia[J]. Marine Pollution Bulletin,2017-01-01,119(1)