DOI: 10.1016/j.marpolbul.2017.06.029
Scopus记录号: 2-s2.0-85020904750
论文题名: Oxidative stress profiles in brain point out a higher susceptibility of fish to waterborne divalent mercury compared to dietary organic mercury
作者: Cardoso O. ; Puga S. ; Brandão F. ; Canário J. ; O'Driscoll N.J. ; Santos M.A. ; Pacheco M. ; Pereira P.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 122, 期: 2018-01-02 起始页码: 110
结束页码: 121
语种: 英语
英文关键词: Brain
; Fish
; Inorganic mercury
; Methylmercury
; Neurotoxicity
; Oxidative stress
Scopus关键词: Brain
; Fisheries
; Health risks
; Mercury (metal)
; Oxidative stress
; Risk assessment
; Toxicity
; Antioxidant defense
; Environmental health
; Fish populations
; Inorganic mercury
; Methyl mercury
; Neurotoxicity
; Oxidative damage
; Protein oxidation
; Fish
; catalase
; glutathione peroxidase
; mercury
; organomercury compound
; reactive oxygen metabolite
; superoxide dismutase
; mercury
; methylmercury derivative
; bioaccumulation
; brain
; fish
; mercury (element)
; methylmercury
; oxidative stress
; toxicity
; animal tissue
; animal well-being
; Article
; benthos
; bioaccumulation
; bioavailability
; chemical analysis
; controlled study
; decomposition
; Diplodus sargus
; disease predisposition
; environmental exposure
; environmental health
; environmental impact assessment
; environmental monitoring
; fish
; lipid peroxidation
; neurotoxicity
; nonhuman
; oxidation
; oxidative stress
; photoperiodicity
; salinity
; spectrophotometry
; toxicokinetics
; water temperature
; animal
; brain
; metabolism
; toxicity
; water pollutant
; Diplodus sargus
; Animals
; Brain
; Fishes
; Mercury
; Methylmercury Compounds
; Oxidative Stress
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: This study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28 days of depuration, which did not occur for Hg(II). Moreover, Hg(II) displayed a high neurotoxicity potential, as unveiled by the poor activation of brain antioxidant defenses and recurrent oxidative damage (as protein oxidation), while the opposite was recorded upon MeHg exposure. These results highlight the need to include Hg(II) in future environmental health assessment plans, preventing an underestimation of the risk for wild fish populations, which has probably been occurring due to the long-standing idea of the higher toxicity of MeHg in comparison with inorganic Hg forms. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88043
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal; Life and Health Sciences Research Institute (ICVS), School of Medicine (EM), Campus of Gualtar, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Environmental Health, Portuguese National Institute of Health, Porto, Portugal; ISPUP-EPI Unit, Universidade do Porto, Rua das Taipas, no. 135, Porto, Portugal; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa, Portugal; Department of Earth and Environmental Science, Center for Analytical Research on the Environment, K.C. Irving Center, Acadia University, Wolfville, Nova Scotia, Canada
Recommended Citation:
Cardoso O.,Puga S.,Brandão F.,et al. Oxidative stress profiles in brain point out a higher susceptibility of fish to waterborne divalent mercury compared to dietary organic mercury[J]. Marine Pollution Bulletin,2017-01-01,122(2018-01-02)