| 项目编号: | 1745530
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| 项目名称: | EAGER: Novel family of cellulose acetate fluorescent nanoparticles for bio imaging applications |
| 作者: | Igor Sokolov
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| 承担单位: | Tufts University
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| 批准年: | 2017
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| 开始日期: | 2017-08-01
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| 结束日期: | 2018-07-31
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| 资助金额: | 81211
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cellulose acetate
; cellulose
; biomedical application
; cellulose derivative
; whole family
; biophotonic application
; ca nanoparticle
; abundant biocompatible material
; fluorescent nanoparticle
; first fluorescent nanoparticle
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| 英文摘要: | Cellulose is one of the most abundant biocompatible materials on earth. Cellulose acetate, viscose, or artificial silk are the most technologically developed and well-characterized derivatives of cellulose, which is completely benign to humans. While various optical materials have been developed from cellulose acetate (CA), optical nanomaterials made of this cellulose derivative are nonexistent. This proposal deals with the development of the first fluorescent nanoparticles and nanofibers made of cellulose acetate (CA), that would make them potentially transformative for biomedical applications.
The project will study CA nano-optical properties then evaluate their potential as labels and sensors for biophotonic applications. Initial work demonstrated the presence of donor-acceptor coupling between encapsulated dyes. Encapsulating hydrophobic fluorescent dyes have many advantages such as exceptional photostability. These features suggest the potential of a new platform for developing a whole family of fluorescent nanoparticles and nanosensors for biomedical applications. There is a clear need to address key exploratory questions to reduce the high risk of this transformative approach. For example, photonic properties of encapsulated dyes inside of CA nanoparticles has not been studied. The role of fluorescent and functional molecules in the particle synthesis is unclear. These questions and others will be addressed in the project. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89579
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Igor Sokolov. EAGER: Novel family of cellulose acetate fluorescent nanoparticles for bio imaging applications. 2017-01-01.
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