| 项目编号: | 1706207
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| 项目名称: | CBET-EPSRC: Hybrid organic-CMOS devices for optogenetic stimulation and lens-free fluorescence imaging of the brain |
| 作者: | Kenneth Shepard
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| 承担单位: | Columbia University
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| 批准年: | 2017
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| 开始日期: | 2017-07-01
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| 结束日期: | 2020-06-30
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| 资助金额: | 308000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | brain
; development
; various brain disease mechanismsthe approach
; time-gated fluorescence detection
; optical imaging approach
; functional imaging
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| 英文摘要: | This collaborative proposal by Dr. Shepard from Columbia University and an international team of researchers from the UK, will develop an optical imaging approach to study freely-behaving animals and potentially humans. The proposal explores original and transformative approaches for overcoming current barriers of functional imaging of the brain. If successful, the platform developed by this project will be critical to many research projects, which will further understanding of the functioning of the brain as well as various brain disease mechanisms
The approach builds on the development of a dense 3D lattice of emitters and detectors embedded onto ultra-narrow implantable neural probes. The proposal includes 3 aims comprising (1) the development of fully integrated high-density optogenetic stimulators, (2) development of time-gated fluorescence detection of lens-free neuronal recordings and (3) in vitro and in vivo characterization and validation of the system. The work includes educational and outreach activities, including; integration of educational material into courses on neuroscience, bioelectronics and biophotonics at Columbia University and at St. Andrews. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89795
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Kenneth Shepard. CBET-EPSRC: Hybrid organic-CMOS devices for optogenetic stimulation and lens-free fluorescence imaging of the brain. 2017-01-01.
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