| 项目编号: | 1641133
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| 项目名称: | NSF/FDA SIR: Micro- and macro-scale validation of diffuse correlation spectroscopy for monitoring functional hemodynamics in the microvasculature of the cerebral cortex |
| 作者: | Jonathan Fisher
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| 承担单位: | New York Medical College
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| 批准年: | 2016
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| 开始日期: | 2016-11-01
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| 结束日期: | 2017-10-31
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| 资助金额: | 79905
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | diffuse correlation spectroscopy
; dcs
; pi
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| 英文摘要: | PI: Fisher, Jonathan
Proposal Number: 1641133
Existing monitoring methods have technological limitations, such as the inability to detect flow changes in small blood vessels, as well as practical ones, such as portability and safety issues involved in bedside monitoring. Cost is an additional limitation for current clinical diagnostics; small hospitals often do not have such capabilities. Transcranial optical techniques such as diffuse correlation spectroscopy (DCS) can provide rapid, real-time monitoring of brain activity for a fraction of the cost of other methods. The PI will evaluate diffuse correlation spectroscopy (DCS) as a noninvasive optical methods for monitoring real-time changes in cerebral blood flow. The proposed research will partner researchers, faculty and postdocs at the New York Medical College, the University of Colorado, the University of Pennsylvania, and the FDA. The proposal includes a well-designed mentoring plan to be implemented by the PI. The plan includes tracking progress through Individual Development Plans; informal discussions to assess satisfaction with the mentoring program' and tracking progress toward career goals.
This project will provide information on the types of changes that can be interrogated using the low-resolution diffuse correlation spectroscopy (DCS) technique. Direct comparison to a high resolution technique will provide necessary information on sensitivity and specificity for DCS. The use of stimulated changes during monitoring will provide the types of necessary detail on the populations of blood vessels that can be assessed. Cerebral blood flow can be used to inform medical interventions in cases of neurological injury or disease. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90823
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Jonathan Fisher. NSF/FDA SIR: Micro- and macro-scale validation of diffuse correlation spectroscopy for monitoring functional hemodynamics in the microvasculature of the cerebral cortex. 2016-01-01.
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