| 项目编号: | 1600932
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| 项目名称: | DISSERTATION RESEARCH: Effects of Reduced Population Size on the Genomics of Adaptation during Drosophila Experimental Evolution |
| 作者: | Michael Rose
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| 承担单位: | University of California-Irvine
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| 批准年: | 2016
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| 开始日期: | 2016-06-01
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| 结束日期: | 2017-05-31
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| 资助金额: | 20085
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | population
; population size
; small population
; selection
; genomic impact
; small census size
; laboratory population
; genomic analysis
; animal research
; present research
; genomic study
; genomic effect
; genomic finding
; good research model
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| 英文摘要: | Reduced population size, and the inbreeding that results from it, is known to reduce the functional response to selection. The present research measures the genomic impact of inbreeding on selection in the common lab fruit fly. Most animal research uses laboratory populations that are inbred, but such inbred animals may not be good research models for species that have large population sizes like humans. Understanding the genomic effects of inbreeding will help elucidate the plight of small populations undergoing intense selection. This is of great importance for such applied settings as conservation since endangered species often have very small populations. The work will also help researchers understand how populations adapt to novel, stressful environments.
The research involves sequencing pooled DNA from nearly 30 Drosophila populations maintained at small census sizes. Half of these populations were subjected to strong selection for starvation resistance, while no selection was directly imposed on the remainder. The functional response to strong selection has already been shown to be impaired in these inbred flies. Genomic analysis will reveal the genetic machinery that has impaired their response to selection. These genomic findings will then be compared to genomic studies of fruit fly populations maintained at much larger population sizes. The comparison will reveal the genetic basis of reduced response to selection with inbreeding.
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| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/92224
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Michael Rose. DISSERTATION RESEARCH: Effects of Reduced Population Size on the Genomics of Adaptation during Drosophila Experimental Evolution. 2016-01-01.
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