| 项目编号: | 1541654
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| 项目名称: | NSF/FDA Scholar-in-Residence at FDA: Understanding the Bioactivity and Safety of Metal and Metal Oxide Nanoparticles Used in Medical Devices |
| 作者: | Zhihong Nie
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| 承担单位: | University of Maryland College Park
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| 批准年: | 2016
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| 开始日期: | 2016-01-15
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| 结束日期: | 2017-12-31
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| 资助金额: | 69920
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | metal
; medical device
; new insight
; multidisciplinary research
; medical safety
; electron spin resonance spectroscopy
; metal oxide np
; nano-bio interaction
; metal oxide nanoparticle
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| 英文摘要: | PI: Nie, Zhihong
Proposal Number: 1541654
The production of reactive oxygen species (ROS) is known as one of the most important reasons for the cytotoxicity of metal and metal oxide nanoparticles (NPs) that are commonly used in medical devices. This project proposes to use electron spin resonance spectroscopy to assess potential toxicity associated with nanoparticles. It aims for new insights and mechanistic knowledge regarding nanoparticle toxicity.
The proposed research will meet the pressing need for identifying the potential hazards of metal and metal oxide NPs used in medical devices. The project has three expected outcomes. First, these studies will offer new insights into the fundamental understanding the ROS generation by nanomaterials in general. Second, it will, for the first time, fully elucidate the role of spatial arrangement of NPs on their ROS generation in biologically relevant environments. Finally, the mechanistic knowledge obtained from this research will guide the better design of safe and effective medical devices or products containing nanoscale materials. The PI will recruit and train students particularly from under-represented groups at both graduate and undergraduate levels into this research program. Students involved in the multidisciplinary research will acquire skills and knowledge crossing in nanomaterials, spectroscopy, nano-bio interactions, and medical safety. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/92928
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Zhihong Nie. NSF/FDA Scholar-in-Residence at FDA: Understanding the Bioactivity and Safety of Metal and Metal Oxide Nanoparticles Used in Medical Devices. 2016-01-01.
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