| 项目编号: | 1510920
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| 项目名称: | UNS: Integrated Tissue Engineering: A Gastrointestinal-Liver Platform to Investigate the Metabolism of Chemicals |
| 作者: | Padmavathy Rajagopalan
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| 承担单位: | Virginia Polytechnic Institute and State University
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| 批准年: | 2014
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| 开始日期: | 2015-09-15
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| 结束日期: | 2018-08-31
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| 资助金额: | USD349999
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | chemical
; liver
; organ
; gi-liver
; gi-liver platform
; tract
; tissue mimic
; change
; weeklong activity
; research objective
; dynamic flow
; complex interaction
; female high school student
; relative contribution
; relevant information
; simplistic monolayer
; complementary action
; padmavathy proposal number
; gi
; defense mechanism
; liver tissue
; 3d multi-cellular hepatic organotypic culture model
; significant lack
; primary intestinal cell sheet
; k-12 educational outreach
; harmful chemical
; dynamic flow condition
; research problem
; statistical analysis
; wide range
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| 英文摘要: | PI: Rajagopalan, Padmavathy
Proposal Number: 1510920
The gastrointestinal (GI) tract and the liver are organs in the body that absorb and metabolize a portion of ingested chemicals and nutrients. As such, they serve as defense mechanisms against harmful chemicals and pathogens. This project focuses on engineering an integrated GI and liver tissue to obtain information on how these organs work in unison to metabolize chemicals.
The metabolism of a wide range of chemicals, drugs, and pharmaceuticals is mediated by the dual and complementary actions of the gastrointestinal (GI) tract and liver. However, there is a significant lack in understanding how integrating tissue mimics of these organs function cohesively. Current studies that use simplistic monolayers fail to capture the complex interactions in vivo. The PI proposes integrating three-dimensional (3D) tissue mimics of the liver and GI to obtain physiologically relevant information on their relative contributions to the biotransformation of chemicals. The changes in the function and properties of each tissue upon exposure to chemicals will be investigated under static and dynamic flow conditions. The following research objectives are proposed. 1. Design an integrated GI-Liver platform using a primary intestinal cell sheet and a 3D multi-cellular hepatic organotypic culture model. 2. Investigate the integrated GI-Liver platform in the presence of dynamic flow. 3. Investigate the effect of chemicals using the GI-liver platform. With regard to broader impacts, the PI will conduct K-12 educational outreach through a weeklong activity for female high school students. The students will learn to identify changes in liver and GI systems upon adding chemicals. This activity will enable students to learn how to identify and formulate a research problem, to conduct statistical analyses, and to work in teams. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93275
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Padmavathy Rajagopalan. UNS: Integrated Tissue Engineering: A Gastrointestinal-Liver Platform to Investigate the Metabolism of Chemicals. 2014-01-01.
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