| 项目编号: | 1508717
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| 项目名称: | EAGER: Collaborative Research: Mimicking mussel adhesion with periodically sequenced polypeptides |
| 作者: | J Herbert Waite
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| 承担单位: | University of California-Santa Barbara
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| 批准年: | 2014
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| 开始日期: | 2015-06-01
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| 结束日期: | 2017-05-31
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| 资助金额: | USD76731
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | adhesion
; work
; eager funding
; research lab
; marine mussel
; research team
; biomimetic adhesion
; mussel foot protein
; eager proposal
; pi
; dopa-rich polypeptide
; robust wet adhesion
|
| 英文摘要: | 1506539 (Tu) / 1508717 (Waite)
The proposed work emphasizes discoveries in bioadhesion, which has the potential to have "far reaching effects" in a number of technologies. Moreover, the ability to generate a significant quantity of a non-toxic biomimetic adhesive has excellent potential for STEM education, where simple demonstrations can be developed to engage students in fundamental science questions as well as the engineering of materials. Additionally, CCNY is a Minority Serving Institution, and the proposed interdisciplinary work is ideal for engaging students at the high-school, undergraduate and graduate levels. The PI has developed a "community" of science teachers at Harlem area schools, where area teachers can work together with high school students in the research lab during the summer and school year. Taken together, the proposed work can both broaden participation in the local STEM community as well as lead to a significant impact in the adhesion and interfacial science community.
Marine mussels use the catecholic amino acid 3,4-dihydroxyphenylalanine (Dopa) in mussel foot proteins to mediate robust wet adhesion in the turbulent intertidal zone. The objective of this EAGER proposal is to quantitatively explore the role of high fidelity sequence periodicity in Dopa-rich polypeptide on the dynamics of coating and adhesion. Moreover, the PIs propose a nonbiological synthetic protocol for the synthesis of a high molecular weight periodic sequence with a low polydispersity, allowing us to synthesize bulk-scale inexpensive polymer. Our approach is based on the application of a transport-limited polycondensation reaction to define both the periodicity and the polydispersity. Subsequently, the PIs propose to quantify the coating dynamics and work of adhesion as a function of the sequence parameters. They will use developed synthetic protocols to precisely control the role of Dopa/proline frequency and the spatial distribution of peptides. This research team has established expertise in both the synthetic methods and the characterization tools, but the proposed work aims at EAGER funding because the vision of marrying polymer-scale synthetic tools and biomimetic adhesion is untested and involves a radically different approach. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94526
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
J Herbert Waite. EAGER: Collaborative Research: Mimicking mussel adhesion with periodically sequenced polypeptides. 2014-01-01.
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