| 项目编号: | 1534687
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| 项目名称: | CAREER: Simultaneous imaging of photoreceptor and post-photoreceptor responses in the retina |
| 作者: | Xincheng Yao
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| 承担单位: | University of Illinois at Chicago
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| 批准年: | 2013
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| 开始日期: | 2014-11-01
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| 结束日期: | 2016-07-31
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| 资助金额: | USD161443
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | post-photoreceptor
; post-photoreceptor neuron
; fast ioss
; photoreceptor
; complex retinal neural network
; post-photoreceptor neural response
; retinal layer
; retinal slice preparation
; retinal neural activity
; frog retinal slice
; retinal cell
; post-photoreceptor response
; early photoreceptor activity
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| 英文摘要: | 1055889
Yao
The research objective of this proposal is to investigate stimulus-evoked intrinsic optical signals (IOSs) associated with photoreceptor and post-photoreceptor neural responses in the complex retinal neural network. This project will start with investigating fast IOSs in frog retinal slices. A retinal slice preparation exposes a cross-section of the retinal layers, and thus allow simultaneous recording of fast IOSs from the photoreceptors and post-photoreceptor neurons, with feasibility of concurrent electrophysiological recording of targeted retinal cells. This phase will test two hypotheses: 1) Fast IOSs correlated with early photoreceptor activities to light stimulation occurs immediately after the stimulus delivery; while fast IOSs associated with second- and third-order post-photoreceptor neurons may have a time delay relative to the stimulus. 2) Fast IOSs can be used to image oscillatory and spike neural activities generated by post-photoreceptor neurons. The second phase of this project is to explore simultaneous optical coherence tomography (OCT) imaging of photoreceptors and post-photoreceptor responses in the intact eye. In order to achieve this objective, an acousto-optic deflector (AOD) based optical coherence tomography (OCT) is proposed for pursuing vibration- and inertia-free optical dissection of retinal neural activities. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95357
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Xincheng Yao. CAREER: Simultaneous imaging of photoreceptor and post-photoreceptor responses in the retina. 2013-01-01.
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