| 项目编号: | 1547267
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| 项目名称: | DISSERTATION RESEARCH: The evolutionary genetics of cellular and biochemical adaptation in Drosophila |
| 作者: | Kristi Montooth
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| 承担单位: | University of Nebraska-Lincoln
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| 批准年: | 2013
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| 开始日期: | 2014-08-14
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| 结束日期: | 2017-03-31
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| 资助金额: | USD20274
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | research
; adaptation
; co-pi
; dissertation research
; environment
; organism
; biochemical adaptation
; evolutionary genetics
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| 英文摘要: | DISSERTATION RESEARCH: The evolutionary genetics of cellular and biochemical adaptation in Drosophila.
PI: Kristi L. Montooth
Co-PI: Brandon S. Cooper
Abstract:
Organisms experience variable environments in both space and time. Variation in factors like temperature and toxic compounds can cause natural selection that results in adaptation to local conditions. At the mechanistic level, these adaptations involve changes in physiological and cellular processes in response to the environment. This research will use techniques from molecular biology, analytical chemistry, genetics and physiology to evaluate the impact of environmental temperature on cell membranes, and of environmental toxicity (e.g., ethanol) on the activities of three enzymes in the ethanol detoxification pathway. Specifically, the research aims to test the prediction that variable temperature environments favor the evolution of cell membrane remodeling, and that efficient detoxification of ethanol depends on interactions between the three enzymes in this pathway. These data will then be used to construct new evolutionary models that help predict the responses of organisms to changing environments.
This project will provide opportunities for undergraduate students from groups underrepresented in the sciences to participate in the research. Outreach to elementary school children at a disadvantaged school, where only 70% passed the state proficiency test for science, will increase scientific literacy. The co-PI collaborates with the local elementary school teachers, providing experiences for the students in basic science and teaching the process of scientific inquiry. Projects will be developed enabling teachers to improve science education at their school. Because this research evaluates the evolution of organismal responses to changing temperatures, the results will also enable the PI and co-PI to provide a better understanding of how organisms respond and adapt to changing environments. Further, the populations of flies collected and constructed will be made available to the scientific community.
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| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96042
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Kristi Montooth. DISSERTATION RESEARCH: The evolutionary genetics of cellular and biochemical adaptation in Drosophila. 2013-01-01.
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