| 项目编号: | 1351936
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| 项目名称: | CAREER: Interior 5D Micro-CT to Analyze Atherosclerotic Plaques In Vivo |
| 作者: | Guohua Cao
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| 承担单位: | Virginia Polytechnic Institute and State University
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| 批准年: | 2013
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| 开始日期: | 2014-08-01
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| 结束日期: | 2019-07-31
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| 资助金额: | USD400000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | micro-ct
; significant impact
; vulnerable plaque
; state-of-the-art micro-ct
; modern reconstruction technique
; guohua caothis project address contemporary challenge
; atherosclerotic plaque imaging
; interior tomography
; medipix detector
; novel interior 5d micro-ct system
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| 英文摘要: | #1351936
P.I.: Guohua Cao
This project addresses contemporary challenges in atherosclerotic plaque imaging of small animals using state-of-the-art hardware components and modern reconstruction techniques, pushes a new frontier of biomedical imaging, and promotes new preclinical applications in mouse models. By synergistically integrating three separately developed components CNT source, Medipix detector, and interior tomography into a novel interior 5D micro-CT system, the resulted whole system is much more than the sum of the components. The system will provide significantly higher spatial and contrast resolution, finer temporal resolution, and lower radiation dose than the state-of-the-art micro-CT. It will transform the method for studying cardiovascular diseases in mice and rats, make a significant impact on atherosclerosis research through facilitating basic mechanistic studies in mice and advancing our knowledge on pathogenesis of atherosclerosis, and has potential in clinical assessment of vulnerable plaques. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96073
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Guohua Cao. CAREER: Interior 5D Micro-CT to Analyze Atherosclerotic Plaques In Vivo. 2013-01-01.
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