| 项目编号: | 1402604
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| 项目名称: | DISSERTATION RESEARCH: Evolution of the metabolome across the Drosophila phylogeny |
| 作者: | Daniel Promislow
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| 承担单位: | University of Georgia Research Foundation Inc
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2015-05-31
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| 资助金额: | USD15828
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | evolution
; metabolomic
; evolutionary change
; evolutionary biology
; protein evolution
; undergraduate researcher
; multiple research approach
; project
; evolutionary time
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| 英文摘要: | Why do some species live longer than others? Scientists have identified molecular pathways that influence the lifespan of model organisms in the laboratory. However, little is known about the underlying mechanisms that account for the enormous variation that we see among species, from mayflies that live for a day, to clams that can live for centuries. This project will use metabolomics to investigate mechanisms that influence lifespan. Metabolomics involves measuring and analyzing the thousands of small molecules (metabolites) circulating within an organism. Enzymatic proteins help regulate metabolite levels, and although protein evolution is well studied, little is known about the evolution of metabolite levels. This project will measure metabolite levels at various ages during the lifespan in ten species of fruit flies (Drosophila spp.) to determine if selection affects the rate at which metabolomic profiles diverge over evolutionary time and if the evolution of fitness traits is tied to evolutionary change in specific biochemical pathways.
This study will be one of the first to use metabolomics to answer evolutionary based scientific questions, and the presentation of the results will enable more scientists to understand the evolution of metabolomics. This project involves the combination of different scientific fields (evolutionary biology, molecular biology, and statistics). As such, undergraduate researchers involved in this project will have the opportunity to learn to combine multiple research approaches, including organismal, molecular, and quantitative, to carry out high-level scientific inquiry. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96764
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Daniel Promislow. DISSERTATION RESEARCH: Evolution of the metabolome across the Drosophila phylogeny. 2013-01-01.
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