| 项目编号: | 1426404
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| 项目名称: | Collaborative Research: pH-Responsive capsules for Enhanced Delivery and Recovery of Cellulases for Biomass Hydrolysis |
| 作者: | Sergiy Minko
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| 承担单位: | University of Georgia Research Foundation Inc
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| 批准年: | 2013
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| 开始日期: | 2014-01-04
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| 结束日期: | 2014-06-30
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| 资助金额: | USD39277
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | unique capsule
; biomass-derived sugar
; biomass hydrolysis
; research group
; simple reuse/recovery process
; nanostructured capsule
; high school researcher
; hybrid organic-inorganic microcapsule
; enzymatic hydrolysis
; enzyme recovery
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| 英文摘要: | 0966526
Minko
Effective, efficient, and economical conversion technologies are needed to meet the potential of using biobased feedstocks to produce liquid fuels and other high-value chemicals. Enzymatic hydrolysis of plant cell wall structural carbohydrates into soluble and fermentable sugars has been technically achievable for decades. Despite significant advances in the past five years, the economical production and use of cellulase enzymes for biomass hydrolysis remain key hurdles. This is true whether one is seeking hydrocarbons or economical cellulosic ethanol.
The key to conquering these obstacles according to the collaborating PIs Minko of Clarkson University in Potsdam, NY and Voronov and Pryor of North Dakota State University at Fargo rests in placing the enzymes in nanostructured capsules. These carefully designed and fabricated, hybrid organic-inorganic microcapsules are loaded with a cocktail of cellulase enzymes for the conversion of cellulose into fermentable glucose. These unique capsules protect the enzymes and preserve their activity, allow for a simple reuse/recovery process for the enzymes, and provide an opportunity to regulate enzymatic reactions using external signals, such as pH. This enzyme recovery and reuse, facilitated through the encapsulation process and magnetic separation, are expected to have significant impacts on processing costs to produce biomass-derived sugars.
The PIs plan to create a website as a means of sharing data and plans between the research groups at the two universities, and to allow public access to follow aspects of the project. They intend to utilize REU opportunities and high school researchers as a part of their outreach efforts. This is a challenging project for all of the researchers. There are many synthetic chemistry components that all must come together in the fabrication of the encapsulated enzymes. The successful development of reversible encapsulation technology for applications of enzymes would have far-reaching implications in a number of industrial processes and would constitute a significant advance in the field. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/97437
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Sergiy Minko. Collaborative Research: pH-Responsive capsules for Enhanced Delivery and Recovery of Cellulases for Biomass Hydrolysis. 2013-01-01.
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