DOI: 10.1016/j.jcou.2019.01.005
Scopus记录号: 2-s2.0-85060796933
论文题名: Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process
作者: Matos R.L. ; Lu T. ; Prosapio V. ; McConville C. ; Leeke G. ; Ingram A.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2019
卷: 30 起始页码: 48
结束页码: 62
语种: 英语
英文关键词: Coprecipitation
; Curcumin
; Dissolution
; PVP
; Supercritical antisolvent process
Scopus关键词: Acetone
; Biochemistry
; Coprecipitation
; Crystallinity
; Dissolution
; Drug delivery
; Ethanol
; Mixtures
; Particle size
; Solubility
; Curcumin
; Enhanced dissolutions
; Operating parameters
; Pharmaceutical formulation
; Polyvinyl pyrrolidone
; Solution concentration
; Solution flow rate
; Supercritical antisolvent process
; Supercritical fluid extraction
英文摘要: The poor solubility of curcumin (CURC) in aqueous media leads to a low bioavailability, which prevents its application in pharmaceutical formulations. In this work, the Supercritical Antisolvent process (SAS) was used to produce coprecipitates of CURC and poly (vinyl pyrrolidone) (PVP) from mixtures of ethanol and acetone. The effects of operating parameters: pressure, temperature, solution concentration, drug/polymer mass ratio and solution flow rate were analysed for a 70-30 (v/v) acetone-ethanol mixture. It was found that the composition of acetone in the solvent mixture is the parameter that affects particle size and curcumin recovery the most. The thermal behaviour, crystallinity, molecular interactions, apparent solubility, release profile of the coprecipitates and possible degradation of curcumin were investigated. The results showed that the SAS process is effective in preparing amorphous formulations of CURC/PVP with an apparent solubility of more than 600 times higher than that of the physical mixture of the raw compounds. © 2019 Elsevier Ltd. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/117299
Appears in Collections: 气候变化与战略
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Recommended Citation:
Matos R.L.,Lu T.,Prosapio V.,et al. Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process[J]. Journal of CO2 Utilization,2019-01-01,30