globalchange  > 气候变化与战略
DOI: 10.1016/j.atmosenv.2020.117574
Title:
Associations of exposure to nitrogen dioxide and major roadways with growth trajectories and obesity at 2 years old: A prospective cohort study
Author: Chen X.; Liao J.; Xu S.; Zhang B.; Wang W.; Cao Z.; Mahai G.; Yang X.; Zhang Y.; Liang S.; Hu K.; Li Y.; Xia W.
Source Publication: Atmospheric Environment
ISSN: 1352-2310
Publishing Year: 2020
Volume: 232
Language: 英语
Keyword: Air pollution ; Housing ; Land use ; Nitrogen oxides ; Nutrition ; Regression analysis ; Trajectories ; Air pollution exposures ; Childhood obesity ; Confidence interval ; Growth trajectories ; Incremental changes ; Land-use regression models ; Nitrogen dioxides ; Prenatal exposure ; Growth rate ; nitrogen dioxide ; atmospheric pollution ; body mass ; cohort analysis ; growth rate ; nitrogen dioxide ; obesity ; pollution exposure ; age ; Article ; body height ; body mass ; body weight ; child ; child growth ; childhood obesity ; cohort analysis ; environmental exposure ; female ; growth rate ; highway ; human ; male ; perinatal period ; prenatal exposure ; prenatal period ; preschool child ; priority journal ; prospective study ; risk factor ; third trimester pregnancy
Subject Area: BMI Z score ; Childhood obesity ; Major roadways ; Nitrogen dioxide ; Prenatal and postnatal exposure
Abstract: Although increasing evidence has documented the association of exposure to air pollution and childhood obesity, a limited number of studies have reported the relationship of air pollution exposure to early childhood body mass index (BMI) growth trajectories, which are strong predictors of future health. We aimed to examine the associations of prenatal and postnatal (first-year and second-year) exposure to nitrogen dioxide (NO2) and indicators of exposure to major roadways with obesity at 2 years old and BMI-for-age Z-score (BMIZ) growth trajectories between 0 and 2 years old. The length and weight of the children were repeatedly measured at birth and at 1 year (±1 month) and 2 years (±1 month) of age. Sex-specific BMIZs were calculated, and children with BMIZs greater than the 95th percentile were identified as cases of obesity (BMIZ cut-offs of childhood obesity were 1.78 for boys and 1.60 for girls). Exposure to NO2 was evaluated using a land use regression model. Two indicators for major roadways exposure (length of major roadways surrounding the residence and residential distance to the nearest major roadway) were calculated according to the residential address during pregnancy. We explored the prenatal NO2 exposure windows associated with incident obesity at 2 years old and found that the third trimester was the prenatal NO2 exposure window with the significant higher risk. Each 10 μg/m3 incremental change in prenatal exposure to NO2 was associated with a relative risk (RR) of 1.10 for childhood obesity (95% confidence interval: 1.01, 1.20). However, postnatal (first-year and second-year) exposure to NO2 was not associated with obesity risk at 2 years old. No significant associations were observed between indicators of exposure to major roadways and risk of obesity at 2 years old. In addition, prenatal exposure to the highest quartile of NO2 was significantly associated with a faster overall growth rate of the BMIZ from birth to the age of 2 years old (the slope of the BMIZ trajectories, β3 (standard error), for the 4th quartile vs. the 1st quartile: 0.88 (0.15), P value < 0.05, P for trend < 0.05). Our study suggested that prenatal exposure to high levels of NO2 may be associated with an increased risk of obesity at 2 years old and a faster overall growth rate of the BMIZ between 0 and 2 years of age. © 2020 Elsevier Ltd
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被引频次[WOS]:1   [查看WOS记录]     [查看WOS中相关记录]
Document Type: 期刊论文
Identifier: http://119.78.100.158/handle/2HF3EXSE/160322
Appears in Collections:气候变化与战略

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Affiliation: Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, China; Wuhan Environmental Monitoring Center, Wuhan, Hubei Province 430000, China

Recommended Citation:
Chen X.,Liao J.,Xu S.,et al. Associations of exposure to nitrogen dioxide and major roadways with growth trajectories and obesity at 2 years old: A prospective cohort study[J]. Atmospheric Environment,2020-01-01,232
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