DOI: 10.1016/j.scib.2020.03.025
论文题名: Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding
作者: Zhang Z. ; Zhai Q. ; Gu Y. ; Zhang T. ; Huang Z. ; Liu Z. ; Liu Y. ; Xu Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期: 15 起始页码: 1268
结束页码: 1280
语种: 英语
中文关键词: Body temperature
; Circadian clock
; Hypothermia
; The dorsomedial hypothalamus
; The suprachiasmatic nucleus
; Time-restricted feeding
英文关键词: Clocks
; Gene expression
; Mammals
; Beneficial effects
; Body temperature
; Circadian clock
; Constant light
; Side effect
; Stress condition
; Suprachiasmatic nucleus
; Transcriptomes
; Physiology
英文摘要: The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-restricted feeding (TRF) has potential as a preventative or therapeutic approach against many diseases. The potential side effects of TRF remain unknown. Here we show that daily 4-h TRF treatment in mice can severely impair body temperature homeostasis and can result in lethality. Nearly half of the mice died at 21 °C, and all mice died at 18 °C during 4-h TRF. This effect was modulated by the circadian clock and was associated with severe hypothermia due to loss of body temperature homeostasis. Remarkably, disrupting the circadian clock by SCN lesions or constant light rescued lethality during TRF. Analysis of circadian gene expression in the dorsomedial hypothalamus (DMH) demonstrated that TRF reprograms rhythmic transcriptome in DMH and suppresses expression of genes, such as Ccr5 and Calcrl, which are involved in thermoregulation. Together, our results demonstrated a potent effect of TRF on body temperature homeostasis and the role of SCN function in this process. Our results further suggested that circadian arrhythmicity can have potential beneficial effects under certain stress conditions. © 2020 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170169
Appears in Collections: 气候变化与战略
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作者单位: Model Animal Research Center, Nanjing University, Nanjing, 210061, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou, 215123, China; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China
Recommended Citation:
Zhang Z.,Zhai Q.,Gu Y.,et al. Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding[J]. Science Bulletin,2020-01-01,65(15)