DOI: 10.1016/j.scib.2020.07.013
论文题名: Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy
作者: Feng X. ; Xu W. ; Liu J. ; Li D. ; Li G. ; Ding J. ; Chen X.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期: 4 起始页码: 362
结束页码: 373
语种: 英语
中文关键词: Chemoimmunotherapy
; Controlled drug release
; Immunogenic cell death
; Polypeptide nanogel
; Remission of Immunosuppression
英文关键词: T-cells
; Tumors
; Anti-tumor efficacy
; Anti-tumor immune
; Co-encapsulation
; Immune suppression
; Immune-modulating effects
; Indoleamine 2 ,3-dioxygenase
; Regulatory t cells
; Tumor microenvironment
; Cell death
英文摘要: Many conventional chemotherapeutics play an immune-modulating effect by inducing immunogenic cell death (ICD) in tumor cells. However, they hardly arouse strong antitumor immune response because the immunosuppressive lymphocytes are present in the tumor microenvironment. These immunosuppressive lymphocytes include regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). We used a low dose of doxorubicin (DOX) to induce ICD in combination with immune regulator 1-methyl-DL-tryptophan (1MT) to suppress indoleamine 2,3-dioxygenase and overcome Treg- and MDSC-associated immune suppression. By co-encapsulation of DOX and 1MT into a reduction-responsive polypeptide nanogel, the drugs were simultaneously released in the tumor cells and synergistically performed antitumor efficacy. After treatment, recruitment of Tregs and MDSCs was inhibited, and the frequency of tumor-infiltrating CD8+ T cells was remarkably enhanced. These results demonstrated that the chemoimmunotherapy strategy effectively suppressed tumor growth without causing evident adverse effects, indicating its great potential in clinical cancer therapy. © 2020 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170248
Appears in Collections: 气候变化与战略
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作者单位: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China
Recommended Citation:
Feng X.,Xu W.,Liu J.,et al. Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy[J]. Science Bulletin,2021-01-01,66(4)