globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.001
论文题名:
Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity
作者: Wang H.; Lin K.; Zhu L.; Zhang S.; Li L.; Liao Y.; Zhang B.; Yang M.; Liu X.; Li L.; Li S.; Yang L.; Wang H.; Wang Q.; Li H.; Fu S.; Zhang X.; Jiang P.; Zhang Q.C.; Cheng J.; Wang D.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Biomarker ; Cancer metabolism ; LDHA ; LINC00973 ; Warburg effect
英文关键词: Cells ; Diagnosis ; Diseases ; Pathology ; Tumors ; Anti-cancer therapies ; Enzymatic activities ; Functional screening ; Glycolytic enzyme ; Lactate dehydrogenase ; Non-coding RNAs ; Potential targets ; Warburg effects ; Enzyme activity
英文摘要: Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancer and essential for metabolism in malignancies, but its regulation and modulation in cancer cells remain poorly understood. Here, using large-scale functional screening, we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973. Notably, knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo. Mechanistically, LINC00973 directly binds to lactate dehydrogenase A (LDHA), an essential glycolytic enzyme, and enhances its enzymatic activity, thereby promoting glycolysis. Clinically, high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers. This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect, and may represent a potential target for broad-acting anti-cancer therapies. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170421
Appears in Collections:气候变化与战略

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作者单位: School of Medicine, Tsinghua University, Beijing, 100084, China; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China; Center for Precision Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

Recommended Citation:
Wang H.,Lin K.,Zhu L.,et al. Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity[J]. Science Bulletin,2021-01-01
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