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DOI: 10.1371/journal.pone.0117106
论文题名:
Carbonate Ion-Enriched Hot Spring Water Promotes Skin Wound Healing in Nude Rats
作者: Jingyan Liang; Dedong Kang; Yingge Wang; Ying Yu; Jianglin Fan; En Takashi
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-2-11
卷: 10, 期:2
语种: 英语
英文关键词: Surface water ; Wound healing ; Macrophages ; Carbonates ; Tissue repair ; Hematoxylin staining ; Ulcers ; Angiogenesis
英文摘要: Hot spring or hot spa bathing (Onsen) is a traditional therapy for the treatment of certain ailments. There is a common belief that hot spring bathing has therapeutic effects for wound healing, yet the underlying molecular mechanisms remain unclear. To examine this hypothesis, we investigated the effects of Nagano hot spring water (rich in carbonate ion, 42°C) on the healing process of the skin using a nude rat skin wound model. We found that hot spring bathing led to an enhanced healing speed compared to both the unbathed and hot-water (42°C) control groups. Histologically, the hot spring water group showed increased vessel density and reduced inflammatory cells in the granulation tissue of the wound area. Real-time RT-PCR analysis along with zymography revealed that the wound area of the hot spring water group exhibited a higher expression of matrix metalloproteinases-2 and -9 compared to the two other control groups. Furthermore, we found that the enhanced wound healing process induced by the carbonate ion-enriched hot spring water was mediated by thermal insulation and moisture maintenance. Our results provide the evidence that carbonate ion-enriched hot spring water is beneficial for the treatment of skin wounds.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117106&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21638
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: School of Medicine, Yangzhou University, Yangzhou, China;Basic Medicine and Nosography, Nagano College of Nursing, Komagane, Japan;Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan;School of Medicine, Yangzhou University, Yangzhou, China;Basic Medicine and Nosography, Nagano College of Nursing, Komagane, Japan;Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan;Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan;Basic Medicine and Nosography, Nagano College of Nursing, Komagane, Japan

Recommended Citation:
Jingyan Liang,Dedong Kang,Yingge Wang,et al. Carbonate Ion-Enriched Hot Spring Water Promotes Skin Wound Healing in Nude Rats[J]. PLOS ONE,2015-01-01,10(2)
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