DOI: 10.1016/j.marpolbul.2017.04.033
Scopus记录号: 2-s2.0-85018651951
论文题名: Effects of polychlorinated biphenyls on metamorphosis of a marine fish Japanese flounder (Paralichthys olivaceus) in relation to thyroid disruption
作者: Dong Y. ; Zhang X. ; Tian H. ; Li X. ; Wang W. ; Ru S.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 119, 期: 1 起始页码: 325
结束页码: 331
语种: 英语
英文关键词: Delayed effects
; Flatfish metamorphosis
; Morphological abnormalities
; Polychlorinated biphenyls
; Thyroid hormones
Scopus关键词: Endocrinology
; Organic pollutants
; Polychlorinated biphenyls
; Abnormal morphology
; Delayed effects
; Environmental concentration
; Flatfish metamorphosis
; Morphological abnormalities
; Paralichthys olivaceus
; Thyroid disrupting chemicals
; Thyroid hormones
; Hormones
; aroclor 1254
; endocrine disruptor
; liothyronine
; polychlorinated biphenyl
; thyroxine
; polychlorinated biphenyl
; thyroxine
; abnormality
; flatfish
; homeostasis
; hormone
; metamorphosis
; morphology
; PCB
; animal experiment
; animal tissue
; Article
; controlled study
; growth retardation
; juvenile
; larva
; metamorphosis
; nonhuman
; Paralichthys olivaceus
; animal
; drug effects
; flounder
; growth, development and aging
; metamorphosis
; thyroid gland
; toxicity
; water pollutant
; Paralichthys olivaceus
; Pleuronectiformes
; Animals
; Flounder
; Larva
; Metamorphosis, Biological
; Polychlorinated Biphenyls
; Thyroid Gland
; Thyroxine
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: This study examined the influence of environmental concentrations of Aroclor 1254 (10, 100, and 1000 ng/L) on metamorphosis of Paralichthys olivaceus, and analyzed the mechanisms in relation to thyroid disruption. Results showed that 100 and 1000 ng/L Aroclor 1254 delayed metamorphosis and that 1000 ng/L Aroclor 1254 caused abnormal morphology. Thyroxine and triiodothyronine levels in the control group were significantly elevated at metamorphic climax, but treatment with 100 and 1000 ng/L delayed the increase in thyroid hormones (THs) and retarded metamorphic processes. In larvae exposed to 1000 ng/L Aroclor 1254, TH levels at metamorphic climax were significantly lower than those of the control group at the same metamorphic stage. We suggest that the effects of Aroclor 1254 on larval metamorphosis can be explained by disruption of thyroid homeostasis. These findings provide a new perspective and biological model for thyroid-disrupting chemicals (TDCs) screening and investigating interference of thyroid function by TDCs. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87590
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Marine Life Science College, Ocean University of China, Qingdao, Shandong Province, China
Recommended Citation:
Dong Y.,Zhang X.,Tian H.,et al. Effects of polychlorinated biphenyls on metamorphosis of a marine fish Japanese flounder (Paralichthys olivaceus) in relation to thyroid disruption[J]. Marine Pollution Bulletin,2017-01-01,119(1)